Intrathecal chemotherapy is a specialized form of chemotherapy where the cancer-fighting drugs are delivered directly into the intrathecal space of the spinal cord. The intrathecal space is a small area within the central nervous system, specifically the area surrounding the brain and spinal cord that is filled with cerebrospinal fluid (CSF). This method allows the chemotherapy drugs to bypass the blood-brain barrier—a protective shield that often prevents many drugs from reaching the brain and spinal cord effectively. Intrathecal chemotherapy is often used when cancer has spread to the central nervous system, such as in cases of leukemia, lymphoma, or certain types of brain cancers. It can also be used to treat or prevent cancers that might affect the cerebrospinal fluid, like meningeal leukemia.
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